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Unlocking Early Detection: A Highly Sensitive Circular Shaped PCF-Based SPR Biosensor for Breast Cancer

Students & Supervisors

Student Authors
Md. Abdullah Nabil
Masters in Electrical and Electronic Engineering, FE
Md. Redowan Habib
Masters in Electrical and Electronic Engineering, FE
Zahid Hasan Rifat
Masters in Electrical and Electronic Engineering, FE
Md. Shihab Sharar Oyon
Masters in Electrical and Electronic Engineering, FE
Supervisors
Prof. Dr. Mohammad Nasir Uddin, Peng.
Professor, Head [graduate Program], FE
Md. Kabiruzzaman
Assistant Professor, Faculty, FE

Abstract

This study presents a new design for a Surface Plasmon Resonance (SPR) biosensor based on a circular Photonic Crystal Fiber (PCF), aimed at detecting two prominent breast cancer cell types: MDA-MB-231 (Type-1) and MCF-7 (Type-2). The sensor features a symmetrical arrangement of air holes and incorporates a thin gold layer applied to the outer surface of the fiber, enhancing the interaction between light and the sensing medium. COMSOL Multiphysics 6.2, employing the Finite Element Method (FEM), is used to simulate and examine the behavior of plasmonic phenomena and light transmission within the proposed sensor design. Results demonstrate strong mode coupling at specific wavelengths, with peak wavelength sensitivities of 11,071 nm/RIU for MDA-MB-231 cells and 14,285 nm/RIU for MCF-7 cells. The circular design of the structure facilitates the gold coating process during fabrication and increases reliability in detecting minor Refractive Index (RI) changes. Overall, this sensor shows considerable promise for accurate, early stage breast cancer detection through optical biosensing techniques.

Keywords

SPR PCF

Publication Details

  • Type of Publication:
  • Conference Name: 3rd International Conference on Big Data, IoT and Machine Learning (BIM 2025)
  • Date of Conference: 25/09/2025 - 25/09/2025
  • Venue: Dhaka International University, Bangladesh
  • Organizer: Dhaka International University, Bangladesh
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